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Evidence Corner

What is the evidence corner?

The Evidence Corner on the Community of Neonatal Nursing Practice website serves as a beacon of knowledge and expertise for neonatal nurses. It is a dedicated space where evidence-based practices, research findings, and clinical insights converge to empower neonatal healthcare professionals. Here, nurses can delve into the latest research studies, clinical guidelines, and best practices in the field, ensuring that their care is informed by the most up-to-date evidence. From critical assessments of interventions to discussions on emerging trends, the Evidence Corner equips neonatal nurses with the tools they need to deliver the highest standard of care to their tiny patients and their families.

Topic: Prophylactic barbiturate use for presentation of morbidity and mortality following perinatal asphyxia

Author conclusion: 

The evidence for the practice of administering prophylactic barbiturates for babies with birth asphyxia was low quality. The studies did demonstrate that the risk of seizures was reduced for infants who received prophylactic barbiturates. Still, the mortality and long-term outcomes did not change compared to infants who did not receive prophylactic barbiturates. It is not recommended to become a routine clinical practice, and barbiturates should be given only to infants with seizures. e.


Citation: ID: CD001240

AU: Young L

AU: Berg M

AU: Soll R

TI: Prophylactic barbiturate use for the prevention of morbidity and mortality following perinatal asphyxia

SO: Cochrane Database of Systematic Reviews

YR: 2016

NO: 5

PB: John Wiley & Sons, Ltd

SN: 1465-1858

KY: Anticonvulsants [*therapeutic use]; Asphyxia Neonatorum [complications, *drug therapy, mortality]; Barbiturates [*therapeutic use]; Humans; Infant; Infant, Newborn; Infant, Premature; Neurodevelopmental Disorders [etiology, prevention & control]; Phenobarbital [therapeutic use]; Phenytoin [therapeutic use]; Randomized Controlled Trials as Topic; Seizures [mortality, *prevention & control]; Thiopental [therapeutic use]

CC: [Neonatal]

DOI: 10.1002/14651858.CD001240.pub3


Topic: Fibreoptic phototherapy for neonatal jaundice

Author conclusion: 

When available, fibreoptic phototherapy is a good alternative to conventional phototherapy for term infants with physiologic jaundice.

Citation: Cochrane Review ID,Author(s),Title,Source,Year,Abstract,Issue,Publisher,ISSN,Keywords,DOI,URL,Cochrane Review Group Code

"CD002060","Mills, JF; Tudehope, D","Fibreoptic phototherapy for neonatal jaundice","Cochrane Database of Systematic Reviews","2001",,"1","John Wiley & Sons, Ltd","1465-1858","Fiber Optic Technology [*methods]; Humans; Hyperbilirubinemia [therapy]; Infant, Newborn; Jaundice, Neonatal [*therapy]; Phototherapy [*methods]; Randomized Controlled Trials as Topic","10.1002/14651858.CD002060","","Neonatal

Topic: Hand hygiene for the prevention of infections in neonates

Kuti BP, Ogunlesi TA, Oduwole O, Oringanje CCMO, Udoh EE, Bello S, Horn D,
Meremikwu MM.

Hand hygiene for the prevention of infections in neonates. Cochrane Database of Systematic Reviews 2023, Issue 6. Art. No.: CD013326. DOI:10.1002/14651858.CD013326.pub4. Accessed 04 April 2024.

Author conclusion: It is important to note that there is insufficient data from RCT to definitively determine the most effective agent for hand washing to prevent neonatal infections. While there is a substantial amount of data from moderate to very low evidence research that suggests the superiority of one form of antiseptic hand hygiene agent over others to prevent neonatal infection this research is not as rigorous as a RCT’s. Consideration should be given to the fact that actual hand-washing techniques, particularly the seven-step and five-moment washing methods, were not measured in RCT research. The author concluded that the available RCT research did not provide sufficient data to make a statement about the best hand hygiene agent or method. The researchers concluded that more well-designed randomized controlled trials are needed to assess how hand hygiene and agent used can prevent noninvasive and invasive infections.

Topic: Caffeine versus other methylxanthines for the prevention and treatment of apnea in preterm infants.

Moresco, Sjogren, Marques, Soll, Bruschettini (2023)

Author conclusion: Caffeine does improve clinical outcomes but there are few studies that compare caffeine to other methylxanthines such as aminophylline. This Cochrane review showed little to no difference in overall mortality, development of bronchopulmonary dysplasia or length of stay. Overall, the comparison between Caffeine and other methylxanthines have an uncertain effect on long-term development. Based on this Cochrane study there is little evidence to support Caffeine over other methylxanthines and they recommended more research especially for the preterm less than 28 weeks. 

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